There is a unique kind of magic that happens in late-night college dorm room chats. For Natalia Neha Khosla and Rachel O’Driscoll, those conversations at Yale’s Saybrook College weren’t just about exams or weekend plans—they were about a shared vision for a better world. Specifically, they were about a paradigm shift in healthcare that would prioritize both the patient experience and the well-being of those providing the care.
Fast forward fifteen years, and those middle-of-the-night dreams have evolved into Simbie AI, a Y Combinator-backed startup that is redefining what it means to run a modern medical practice. Natalia, now an MD and MSc, recently shared this journey during an Accelerate Yale webinar, reflecting on the transition from first-time founders to leaders in the rapidly evolving landscape of agentic AI.
The Problem: A Healthcare System at Its Breaking Point
The reality of today’s healthcare environment is stark. Administrative overload isn’t just a buzzword; it’s a systemic crisis. Medical practices are grappling with high turnover, staggering training costs, and the constant threat of human error in manual processes. Perhaps most concerning is the level of physician and staff burnout, which directly impacts the quality of patient care.
“Those middle of the night chats in Saybrook College turned into our life’s work, together.” — Natalia Neha Khosla, MD, MSc
When Natalia and Rachel set out to build Simbie AI, they weren’t just looking to create another piece of software. They were looking to build an AI medical staff—a 24/7 support system that could handle the heavy lifting of administrative work, allowing human clinicians to focus on what they do best: treating patients.
The Solution: Smarter, Faster, and Always-On AI Clinical Agents
Simbie AI’s platform is built on the concept of agentic AI—autonomous agents that don’t just provide information but actually perform tasks. These AI clinical agents are designed to automate the entire follow-up process after a patient visit, from managing results and orders to handling automated refills and scheduling.
| Feature | Description | Impact on Practice |
| Smart Call Management | Handles 100s of simultaneous inbound and outbound calls with zero hold time. | Eliminates missed calls and improves patient satisfaction. |
| EMR Integration | Seamlessly connects with existing Electronic Medical Record systems. | Reduces manual data entry and ensures accuracy in patient charts. |
| Patient Registration & Intake | Collects pre-visit HPI and manages registration details automatically. | Streamlines the front-desk experience and reduces wait times. |
| Automated Refills & Scheduling | Queues refills and reads chart notes to answer patient questions. | Frees up staff from repetitive, time-consuming tasks. |
Why Experience Matters: Building in a Regulated Industry
One of the key takeaways from Natalia’s recent talk was the challenge of building in a highly regulated industry like healthcare. Navigating the pace of AI breakthroughs while maintaining strict HIPAA compliance and ensuring patient safety requires more than just technical skill—it requires a deep understanding of the clinical environment.
By integrating directly into existing workflows, Simbie AI provides a “digital front door” for practices, offering 24/7 coverage that a traditional human-only staff simply cannot match. The result? A 60% saving on administrative staff costs and a significant boost in both patient and provider morale.
Join the Revolution in Patient Care
The journey from a Yale dorm room to the forefront of the AI revolution has been one of passion, friendship, and a relentless commitment to improving healthcare. As we move further into the age of agentic AI, the goal remains the same: simplifying the post-visit period for everyone involved.
Are you ready to see how an AI-powered medical staff can transform your practice? Whether you’re looking to reduce costs, eliminate burnout, or simply provide a better experience for your patients, the future of healthcare is here.